ACIDOSTAT

 

ACIDOSTAT based on sodium alginate, carbonate and bicarbonate.

 

Sodium alginate - Extracted from seaweed

• Unique properties used in GERD*; Heartburn; Regurgitation
• Interacts with the acids (HCl) in the stomach
• It forms a gel-like substance (raft) – see image A
• It floats on top of the stomach content and acts as a physical barrier
• It prevents the acid from rising into the esophagus
• It acts very quickly (in minutes) for immediate relief
• In combination with different types of carbonates, after CO2 (carbon dioxide) release, alginate captures CO2 bubbles so it has a lower density than the contents of the stomach and will float for a long time with prolonged effect – Image B
• *GERD = Gastroesophageal Reflux Disease

Reference

Raja Ali, Raja Affendi & Hassan, Jamiyah & Egan, Laurence. (2022). Review of recent evidence on the management of heartburn in pregnant and breastfeeding women. BMC Gastroenterology. 22. 10.1186/s12876-022-02287-w.

Kim HM. Raft Formation of Sodium Alginate in the Stomach. J Neurogastroenterol Motil. 2016 Oct 30;22(4):705-706. doi: 10.5056/jnm16068. PMID: 27605509; PMCID: PMC5056581.

Image A

Referință imagine A: Ali, R.A.R., Hassan, J. & Egan, L.J. Review of recent evidence on the management of heartburn in pregnant and breastfeeding women. BMC Gastroenterol 22, 219 (2022). https://doi.org/10.1186/s12876-022-02287-w

Raft formation – sodium alginate

Image B

Referință imagine B: Kim HM. Raft Formation of Sodium Alginate in the Stomach. J Neurogastroenterol Motil. 2016 Oct 30;22(4):705-706. doi: 10.5056/jnm16068. PMID: 27605509; PMCID: PMC5056581.

 

Calcium carbonate (CaCO₃)

•      It is an antacid

•      It reacts with gastric acid (HCl)

•   Improves the motor function of the esophagus, thereby improving acid clearance from the esophagus to the stomach

•      It provides 120 minutes of acid neutralization (long lasting effect)

•      15-30% of calcium is absorbed (good source for calcium intake)

 

Sodium carbonate (Na₂CO₃)

• It is an antacid with slower and prolonged effect
• It is a strong basic inorganic salt that acts by neutralizing hydrochloric acid in the stomach
• It has cytoprotective effects
• Released CO2 increases the effect of alginate

 

Sodium bicarbonate (NaHCO₃)

• It is an antacid with very rapid action
• It acts by neutralizing hydrochloric acid in the stomach quickly, thus reducing symptoms very fast (minutes)
• It has cytoprotective effects
• Released CO₂ increases the effect of alginate
  

Reference:

Garg V, Narang P, Taneja R. Antacids revisited: review on contemporary facts and relevance for self-management. J Int Med Res. 2022 Mar;50(3):3000605221086457. doi: 10.1177/03000605221086457. PMID: 35343261; PMCID: PMC8966100.

Pregnancy and lactation

•      At the recommendation of the healthcare specialist, it is possible to administer the lowest effective dose:

•      ½ or 1 tablet, as needed, without exceeding 3 tablets per day, for maximum 5 days

Proton pump inhibitors (PPI)

•      Since PPIs have a maximum effect after 3-5 days, simultaneous administration of ACIDOSTAT is recommended for the rapid reduction of symptoms for 5 days

•      After the first 5 days of PPI treatment, ACIDOSTAT can be administred as needed, while continuing with PPI

Potential drug interactions

•      Due to the calcium content, simultaneous administration with some drugs is avoided: fluoroquinolones, tetracyclines, digoxin, iron salts, biphosphonates, PPI, thyroid hormones etc.

To eliminate interactions, drugs are administered two hours apart from ACIDOSTAT

 

When and how to take ACIDOSTAT

•         Recommended in gastric hyperacidity, acid reflux and poor digestion with hyperacidity

•         Usually take 1-2 tablets, as needed, when the symptoms are bothersome

•         Not to exceed a maximum of 6 tablets per day

•         The tablets are allowed to dissolve slowly in the oral cavity, or it can be crushed and swallowed

•         Do not use in children under 6 years of age and for more than five days continuously.

 

Why ACIDOSTAT

• Transforms irritating gastric acid into harmless water and CO₂ in just a few minutes
• Proven raft formation in human subjects (anti-reflux effect)
• It contains fast- and slow acting antacids in combination with alginate – triple effect
• It protects the gastric mucosa
• Antiacid and anti-reflux effects
• Has rapid effect with prolonged action (2-6 hours)
• Can be used by children above 6 years of age, pregnant people, lactating women and by diabetic patients (no sugar)
• Synergistic active ingredients

 

INSTRUCTIONS FOR USE

Take 1-2 tablets in case of gastric hyperacidity.

FUNCTIONAL INGREDIENTS:

Bulking agent: sorbitol*; sodium alginate; calcium carbonate; sodium bicarbonate; 
sodium carbonate; anti-caking agents; silicon dioxide, magnesium salts of fatty acids; 
flavor; sweetener: sucralose.

Presentation: 20 tablets

Active ingredients:

Active substances	Per one tablet
Sodium alginate	250 mg
Calcium carbonate •      Calcium	133.50 mg •      80.14 mg	%Daily Value – To be completed
Sodium bicarbonate	133.50 mg
Sodium carbonate	133.50 mg
Sorbitol	Sweetener 0.75 kcal

 

 

DETALII:

FORMAT	20 tablets of 1000 mg
CODE EAN	0803173153128